The causal relationship between ankylosing spondylitis and the risk of ovarian cancer.

OBJECTIVE: The aim of this study was to investigate the potential causal relationship between ankylosing spondylitis (AS) and ovarian cancer. METHODS: We conducted analyses utilizing publicly available pooled statistical data sets from genomewide association studies (GWAS) involving individuals of European ancestry. Our objective was to identify single nucleotide polymorphisms (SNPs) significantly associated with AS and use them as instrumental variables to assess the causal relationship between AS and ovarian cancer. We employed three statistical methods for two-sample Mendelian randomization: inverse variance weighting (IVW), weighted median, and MR-Egger regression. Network MR Analysis revealed the mediating role of tumor necrosis factor receptor superfamily member 21 between ankylosing spondylitis and ovarian cancer. RESULTS: From the GWAS on AS, we selected 23 instrumental SNPs that exhibited genome-wide significance. Our findings consistently demonstrated an association between AS and ovarian cancer using multiple statistical methods (IVW: odds ratio (OR) 1.147, 95% confidence interval (CI) 1.022-1.287; weighted median estimator: OR 1.177, 95% CI 1.009-1.373; MR-Egger regression: OR 1.166, 95% CI 0.958-1.418). These results indicate a positive correlation, suggesting that AS is associated with an increased risk of ovarian cancer. Furthermore, there was no evidence to suggest that the observed causal effect between AS and the risk of osteoarthritis was influenced by genetic pleiotropy (MR-Egger intercept = -0.0010644, P = 0.8433359). In addition, tumor necrosis factor receptor superfamily member 21 mediated 10.2% of the total effect size in the development of ankylosing spondylitis on ovarian cancer risk. CONCLUSION: Our Mendelian randomization analysis provides strong evidence supporting a potential causal relationship between AS and ovarian cancer risk, with ankylosing spondylitis clearly associated with an increased risk of ovarian cancer. Tumor necrosis factor receptor superfamily member 21 as a mediator involved in the occurrence and development of these two diseases.

Investigating the effects of polymer plugging mechanism of liquid production decrease and improvement by the cross-linked gel performance.

Polymer flooding, as the most successful and well-known chemical EOR method was broadly applied around the world. Mostly, contrasted with Waterflooding, the production rate decrease during polymer flooding is smaller based on field application. Nevertheless, the production liquid rate decreased critically in the middle phase to late phase due to plugging, which could lead the way to poor flooding performance and fewer cumulative oil. In this work, first, we approached the affecting polymer plugging mechanism model on liquid production decrease to investigate the parameters such as; solid-phase concentration (SOLIDMIN), reacting frequency factor (FREQFAC) and others affecting components are all investigated consecutively. Secondly the model approached by cross-linked gel for the improvement of production liquid rate. The physical work was designed by a physical model, and then the polymer adsorption that generating blockage emerging in permeability diminish assessed by a mathematical model. The outcomes specify that the existence of this debris, excessive assemblage of solid-phase and the excessive reactant frequency factor has major mechanical and physical parameters effects on the reservoir throughout polymer flooding. Polymer flood model base case liquid ratio loss is 11.15 m3/day between the years 2014-08-01 to 2020-03-04. Comparing with the polymer flood model case 1, liquid ratio loss ranging to 1.97 m3/day between the years 2014-08-02 to 2020-03-03. While the oil ratio loss of the polymer flood base case model between the years 2015-07-08 to 2020-03-04 attained 12.4 m3/day contrasting with the polymer flood model case 1 oil ratio increase to 0.37 m3/day between the years 2014-08-04 to 2019-04-02. The cross-linked gel model base case liquid ratio loss is 2.09 m3/day between the years 2015-01-02 to 2020-02-03, while the oil ratio lost reached 9.15 m3/day between the years 2015-09-01 to 2020-02-03. Contrasting with the cross-linked gel model case 2 liquid ratio recovered from the loss and attained 25.43 m3/day in the year 2020-12-01, while the oil ratio is reached 15.22 m3/day in the year 2020-12-01. Polymer flood model examined through cross-linked gel model performed reliable outcomes by taking out the plugging, which also occasioned the reservoir production rate to decrease. With the application of cross-linked gel the affected parameters and the production rate have achieved an improvement.